Rehling, Peter, Prof. Dr.
Professor, Director of the Dept. of Cellular Biochemistry
- 1996 Dr. rer. nat. (Biology), University of Bochum
- 1996 - 1998 Postdoctoral fellow (Laboratory of W.-H. Kunau, Bochum)
- 1998 - 2000 Postdoctoral fellow (S.D. Emr, HHMI, University of California San Diego, USA)
- 2000 - 2004 Research Group leader at the Institute for Biochemistry and Molecular Biology, Freiburg
- 2003 Habilitation (Biochemistry and Molecular Biology), University of Freiburg
- 2004 - 2007 Assistant Professor Institute for Biochemistry and Molecular Biology, Freiburg
- Since 2007 Professor of Biochemistry and Director of the Dept. of Cellular Biochemistry University of Göttingen
- Since 2009 Speaker of the Study Section “Molecular Cell Biology” of the German Society for Biochemistry and Molecular Biology (GBM)
- Since 2010 Group associated with the Max-Planck-Institute for Biophysical Chemistry
Major Research Interests
We are interested in understanding the molecular mechanisms by which proteins are transported across the mitochondrial membranes and to find out how multi-protein complexes in the inner membrane (TIM complexes; translocation machineries of the inner membrane) mediate this task. In another aspect of our work we addresses the question how newly imported proteins assemble into multi-protein complexes in the inner membrane. In case of the respiratory chain complexes the assembly process is especially demanding since central subunits of the complexes are made within mitochondria. Dedicated chaperone- like factors are required to assist and regulate assembly and translation in mitochondria. The analysis of the principles of the biogenesis process and the activities of the assembly factors is of central importance for our understanding of the molecular basis of human mitochondrial disorders.
Homepage Department/Research Group
- Richter-Dennerlein R, Oeljeklaus S, Lorenzi I, Ronsör C, Bareth B, Schendzielorz AB, Wang C, Warscheid B, Rehling P*, Dennerlein S (2016) Mitochondrial protein synthesis adapts to influx of nuclear-encoded protein. CELL 67: 471-483 (*corresponding and lead author)
- Richter-Dennerlein R, Dennerlein S, Rehling P (2015) Integrating mitochondrial translation into the cellular context. Nature Rev. Mol. Cell Biol. 16: 586-592.
- Dudek J, Cheng I Chowdhury A, Wotnzy K, Balleininger M, Reinhold R, Grunau S, Callegari S, Toischer K, Wanders RJA, Hasenfuß G, Guan K, Brügger B, Guan K, Rehling P (2016) Cardiac-specific Succinate Dehydrogenase Deficiency in Barth Syndrome. EMBO Mol. Med. 8: 139-154
- Schulz C, Rehling P (2014) Remodeling of the active presequence translocase drives motor-dependent mitochondrial protein translocation. Nature Commun. 10: 5:4349.
- Mick D.U, Dennerlein S, Wiese H, Reinhold R, Pacheu-Grau D, Lorenzi I, Sasarman F, Weraarpachai W, Shoubridge EA, Warscheid B, Rehling P (2012) MITRAC links mitochondrial protein translocation to respiratory-chain assembly and translational regulation. CELL 151: 1528-1541.