Research Areas

Modification, specific detection and conformational switching of oligonucleotides, peptides and proteins. Examination of suitable model systems; influencing function and properties by synthesising analogues of biomolecules.


  • Synthesis of linear DNA base-stack models, application in DNA diagnostics, electron transfer and intercalation studies; enzyme mimetics.
  • Molecular architecture: reversible helix and beta strand organisation, higher aggregates.
  • Conformational switch in peptides and proteins.
  • Stabilisation of Z-DNA; induction of bent DNA.
  • Unnatural amino acids in peptides and proteins.
  • DNA double helix detection



For further information please see Homepage von Prof. Diederichsen.



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